I've had mild scoliosis since birth, it didn't affect me for a long time, probably no major problems well into my early 20s. Since then, it got progressively worse, but not so severe that I couldn't deal with it.
Now I'm older, it's hitting with a vengeance though, because it in a way started to set off a chain reaction, from neck and shoulder problems to sacroiliac joint pain. I start to get back pains when I walk for longer than 10 minutes (still doing it nevertheless), and it does affect me in my singing when I have a bad day, because my whole muscular balance is off kilter.
It is uncomfortable, but you find your strategies to deal with it I guess. I have a good physio, and I also see an Alexander practitioner regularly. It would be a lie to say though it doesn't affect me ...
Edit: As for the violin: I was a much more active violin player when I was younger, and back then, the scoliosis had virtually no effect on me, but that was before I literally started feeling the pain. Today, I only play the violin occasionally, and I find it's okay. It hurts a bit in my lower back if I am standing for a long time, but that happens in general, not only when I am playing the violin. I consciously watch that I don't twist too much, or shift too much weight to one side, and then it tends to be okay. For me personally, sitting with good posture is usually more comfortable than standing, but that's not always an option