It depends what you want it for to be honest.
If you're going to be playing in a band then chances are all you'd need your amp to do is overcome the level of a drumkit, in which case a good 60w amp should suffice. It'd be just your own personal monitor as you'd probably take a DI into a PA system.
However, if you're looking to be a one man show normally, you'll need to fill a whole room, and to do that comfortably you need to be looking 120w and above I'd say. There are a number of "two in one" amps out there at the moment which have two channels, one for plugging in your instrument and an XLR input for a microphone. They come with EQs and balancing tools so your whole sound comes out of one box.
My guitar rig is a 150w Spider II with 2x12" Celestions and that fits in the boot no problem at all. I wouldn't worry about getting it in a car. I had a Renault Clio and could get 3 guitars, 2 amps, a power amp, 24 channel mixing desk, drum hardware, 2x15" loudspeakers and their stands all at the same time! I just don't know how legal is was.